Ginger works (for me at least ) within 15 minutes. Turmeric supposedly works cumulatively over time. Choose your brand of turmeric carefully. There have been a number of articles about people using turmeric supplements who gotten sick from heavy metal poisoning. Turmeric can absorb heavy metals from the soil, but most of the contamination comes from primary sources add the heavy metals in for various reasons. Some supplement companies have good reputations for monitoring their sources for contamination. Of course, those supplement are more expensive. Thorne is one of those companys.