Yeah I mean in the court of public opinion, sure. But legally and in criminal court, it cant be considered for assessing someones guilt. Even Trump himself has said that anyone who pleads the fifth is obviously guilty. Then he himself went on to plead the fifth hundreds of times lol.
In subreddit r/law
In a post titled:
Jeffrey Epstein asserts his 5th, 6th, and 14th Amendment rights when asked if he socialized with Donald Trump in the presence of females under the age of 18